Table 2.
Last visit# values for LVEF, myocardial T2*, LIC ferritin and 6 minute walk
|
Patient |
Arm |
DFO |
DFO |
LVEF |
T2* |
LIC |
Ferritin |
6 minute |
|---|---|---|---|---|---|---|---|---|
| |
|
Route |
Dose |
% |
ms |
mg/g dw |
μg/L |
Walk |
| hr/d | mg/kg/d | Final | Final | Final | Final | Distance m | ||
| 1a |
Comb |
SC,12 |
52 |
56.0 |
5.7 |
27.7 |
3628 |
492 |
| 2a |
Comb |
SC,10 |
51 |
56.6 |
6.3 |
nd |
2747 |
554 |
| 3a |
Comb |
IV, 24 |
59 |
39.2 |
3.1 |
4.0 |
1154 |
378 |
| 4a |
Comb |
SC,12 |
53 |
51.3 |
9.2 |
2.8 |
1811 |
516 |
| 5a |
Comb |
IV, 8 |
51 |
58.0 |
6.0 |
6.8 |
3008 |
352 |
| 6a |
Comb |
SC,12 |
50 |
61.1 |
20.8 |
16.1 |
4727 |
352 |
| 7a |
Comb |
IV, 12 |
46 |
59.6 |
19.2 |
2.9 |
343 |
550 |
| 8a |
Comb |
SC,13 |
40 |
nd |
nd |
nd |
nd |
na |
| 9a |
Comb |
SC,14 |
44 |
61.6 |
20.8 |
2.1 |
622 |
475 |
| 10a |
Comb |
SC,12 |
50 |
54.6 |
3.9 |
7.7 |
1130 |
397 |
| 11a |
Comb |
SC,12 |
50 |
65.4 |
3.5 |
1.7 |
200 |
364 |
|
mean |
|
12.9 |
49.6 |
56.3 |
9.8 |
8.0 |
1937.0 |
443 |
| SD |
|
|
5.0 |
7.2 |
7.4 |
8.7 |
1528.0 |
82.8 |
| 1b |
Mono |
SC, 10 |
49 |
50.9 |
11.3 |
14.6 |
4409 |
689 |
| 2b |
Mono |
SC,12 |
60 |
nd |
nd |
nd |
439 |
na |
| 3b |
Mono |
IV, 24 |
50 |
nd |
nd |
nd |
v high |
na |
| 4b |
Mono |
IV, 24 |
41 |
53.3 |
9.4 |
13.8 |
2540 |
590 |
| 5b |
Mono |
SC,14 |
30 |
51.6 |
12.8 |
1.3 |
890 |
563 |
| 6b |
Mono |
SC,14 |
23 |
66.9 |
9.9 |
2.1 |
413 |
578 |
| 7b |
Mono |
SC,12 |
8 |
49.6 |
3.3 |
3.3 |
152 |
410 |
| 8b |
Mono |
SC,12 |
50 |
58.2 |
4.0 |
2.3 |
2360 |
398 |
| 9b |
Mono |
SC,12 |
50 |
nd |
nd |
ns |
ns |
ns |
|
mean |
|
14.9 |
40.1 |
55.1 |
8.4 |
6.2 |
1600.4 |
538 |
| SD | 16.6 | 6.5 | 3.9 | 6.2 | 1565.7 | 112.9 |
# Last visit uses data obtained at the last visit for each patient : this may be at 12 months, 6 months or before this time. Mean values include patients who completed and who did not complete 12 months of treatment; the latter patients are shown in italics. Statistics are not used from this Table as the pre-planned analysis was on longitudinal data shown in the figures.
Comb (Combination) = DFP + DFO. Mono (monotherapy) = DFO alone. SD = standard deviation of the mean. nd = not done. SC = subcutaneous, IV = intravenous.