Figure 4. Top three networks identified by Ingenuity associated functional network analysis of genes hypermethylated in > 30% of chromophobe RCC samples. Methylated genes are shown in gray and connecting genes in white. Solid arrows represent direct interaction, dashed arrows highlight indirect interactions, solid joining lines identify protein binding only. IPA analysis identified several key networks with the top three showing interactions and involvement in embryonic development, tissue development and morphology, cell signaling, molecular transport, vitamin and mineral metabolism, cell death and survival, cell cycle and cancer.