Figure 5. Top three networks identified by Ingenuity associated functional network analysis of genes hypermethylated in > 30% of renal oncocytoma samples. Methylated genes are shown in gray and connecting genes are in white. Solid arrows represent direct interaction, dashed arrows highlight indirect interactions, solid joining lines identify protein binding only. IPA analysis identified networks with involvement in cell signaling and molecular transport, cell morphology, cellular assembly and organization, cellular function and maintenance, cancer, cellular growth and proliferation, and renal and urological disease.