Table 1. Precision and accuracy for the determination of olanzapine and N-desmethyl-olanzapine in spiked plasma.
Analyte | Spiked concentration (ng/mL) | Repeatability (CV %) | Accuracy (Error %) | Interday Precision (CV %) | Interday Accuracy (Error %) | Recovery (%) |
olanzapine | 1 | 19.76 | –12.89 | 12.35 | –12.17 | 73.26 |
5 | 13.19 | 3.92 | 8.73 | –8.91 | 88.08 | |
20 | 2.66 | –11.65 | 3.99 | –7.08 | 84.90 | |
40 | 2.50 | 7.81 | 2.56 | 8.22 | 84.38 | |
100 | 0.46 | –1.08 | 3.87 | –1.24 | 93.83 | |
N-desmethyl-olanzpine | 1 | 14.69 | –4.04 | 6.95 | –16.45 | 73.46 |
5 | 8.31 | 11.76 | 13.95 | –5.66 | 83.68 | |
20 | 8.64 | –5.73 | 8.23 | 6.53 | 89.13 | |
40 | 3.27 | 7.92 | 3.08 | 5.83 | 78.31 | |
100 | 5.63 | –3.86 | 5.08 | –2.23 | 90.41 |