Table 3. Correlations of olanzapine or desmethylolanzapine to individuals’ metabolic parameters in patients with schizophrenia (n = 48).
| DMO | DMO C/D | OLZ | OLZ C/D | |
| Glucose | ||||
| rs = | –0.45† | –0.42 | –0.08 | –0.11 |
| p = | 0.00147 | 0.00335 | 0.609 | 0.469 |
| Insulin | ||||
| rs = | –0.40 | –0.39† | –0.16 | –0.19 |
| p = | 0.00538 | 0.00608 | 0.283 | 0.191 |
| c-peptide | ||||
| rs = | –0.22 | –0.27 | 0.06 | –0.06 |
| p = | 0.128 | 0.0593 | 0.677 | 0.701 |
| Homocysteine | ||||
| rs = | +0.38 | 0.28 | 0.04 | –0.04 |
| p = | 0.00801 | 0.0587 | 0.786 | 0.801 |
| Prolactin | ||||
| rs = | 0.08 | 0.11 | 0.09 | 0.10 |
| p = | 0.591 | 0.451 | 0.551 | 0.504 |
| Uric acid | ||||
| rs = | –0.09 | –0.20 | 0.0331 | 0.0285 |
| p = | 0.545 | 0.177 | 0.822 | 0.846 |
| Cholesterol | ||||
| rs = | 0.04 | –0.02 | 0.01 | 0.10 |
| p = | 0.773 | 0.889 | 0.934 | 0.485 |
| Triglyceride | ||||
| rs = | –0.10 | –0.19 | –0.07 | –0.07 |
| p = | 0.474 | 0.192 | 0.621 | 0.624 |
Plasma olanzapine or desmethylolanzapine concentrations corrected by individual’s dosage were expressed as OLZ C/D or DMO C/D.
Spearman’s correlation coefficients were expressed as rs and p values were uncorrected for multiple comparisons.
†
Correlations remain statistically significant following post hoc modified Bonferroni correction (adjusted p value <0.05).