Table 1. Metabolic parameters of different groups of mice fed with a HFD.

Parameters	WT	AK	IK	DK
Body weight at week 0 (g)	21.26±0.94	21.11±0.81	21.44±1.04	21.38±1.02
Body weight at week 12 (g)	32.41±1.09	37.44±2.12* #	31.55±0.53△	32.66±0.87△
TG (mmol/L)	1.58±0.68	3.31±0.69* #	1.17±0.48△	3.49±0.53* #
TC(mmol/L)	5.88±0.71	20.28±2.54* #	5.01±0.55△	22.71±2.12* #
Gram food intake per body weight(g/g)	0.105±0.053	0.121±0.044	0.108±0.054	0.115±0.052
LDL(mmol/L)	0.85±0.22	6.23±1.47* #	0.58±0.37△	6.44±1.55* #
HDL(mmol/L)	1.73±0.87	0.68±0.14* #	2.16±0.68△	0.57±0.19* #

Body weight was measured at the beginning and after 12 weeks of exposure to a HFD. Serum TC, LDL, HDL and TG levels were measured after 12 weeks of exposure to a HFD. Gram food intake per body weight was measured every morning through the weighing of the HFD, and mice of each group were measured at three different time points from week 0, 6 to 12 to obtain the average food intake. Values are means ± SD; n = 8 per group.

^*P<0.05 vs. WT;

^#P<0.05 vs. IK;

△P<0.05 vs. AK.