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. 2013 May 31;8(5):e65614. doi: 10.1371/journal.pone.0065614

Figure 1. LTBP4 is downregulated in gastrointestinal cancer.

Figure 1

A) LTBP4 protein expression levels were assessed by immunohistochemistry in tissue microarrays of patient adenocarcinomas (AC) of esophagus, stomach, pancreas, small intestine and colon compared to normal tissue of the same organ. B) LTBP4 protein expression levels were assessed by immunohistochemistry in patient tissues of esophageal cancer progression compared to normal esophageal tissues in tissue microarrays. C) Immunohistochemical evaluation of LTBP4 expression in normal esophagus, esophageal adenocarcinoma (EAC) stage II, EAC stage III and in a distant lymph node metastasis. Black arrows indicate LTBP4-positive staining. Data are presented ± standard deviation and *p<0.05, **p<0.01 versus normal tissue. Bar graphs: 50 µm.