Table 6. Mean subjective ratings1 of irritable bowel syndrome (IBS) symptom severity at baseline and during weeks 4 and 8 of treatment with B. infantis 35624 or placebo recorded in subjects with IBS. Post-baseline means are least squares meaans from the statistical mixed model.
| Symptom | Study Visit | Treatment Groups | |||
|---|---|---|---|---|---|
| |
|
B. infantis 35624 (log 10 ng DNA g−1) |
Placebo (log 10 ng DNA g−1) |
|
|
| |
|
Mean (SE) |
Mean (SE) |
Difference (SE) |
p-value |
| Abdominal pain |
Baseline |
2.39 (0.141) |
2.50 (0.145) |
|
|
| |
Week 4 |
2.15 (0.164) |
1.97 (0.171) |
0.18 (0.237) |
0.438 |
| |
Week 8 |
1.99 (0.161) |
1.73 (0.170) |
0.26 (0.234) |
0.261 |
| Bloating |
Baseline |
2.47 (0.156) |
2.42 (0.160) |
|
|
| |
Week 4 |
2.15 (0.160) |
2.01 (0.166) |
0.14 (0.230) |
0.541 |
| |
Week 8 |
2.01 (0.157) |
1.89 (0.166) |
0.13 (0.229) |
0.576 |
| Urgency |
Baseline |
2.38 (0.136) |
2.20 (0.139) |
|
|
| |
Week 4 |
2.04 (0.157) |
1.96 (0.163) |
0.08 (0.227) |
0.728 |
| |
Week 8 |
1.95 (0.163) |
1.70 (0.173) |
0.25 (0.238) |
0.287 |
| Incomplete evacuation |
Baseline |
2.24 (0.170) |
2.18 (0.174) |
|
|
| |
Week 4 |
1.94 (0.158) |
1.94 (0.165) |
0.00 (0.228) |
0.992 |
| |
Week 8 |
1.77 (0.165) |
1.65 (0.175) |
0.12 (0.240) |
0.611 |
| Straining |
Baseline |
1.98 (0.171) |
1.90 (0.176) |
|
|
| |
Week 4 |
1.77 (0.159) |
1.65 (0.165) |
0.12 (0.229) |
0.592 |
| |
Week 8 |
1.57 (0.166) |
1.56 (0.176) |
0.01 (0.242) |
0.965 |
| Gas |
Baseline |
2.45 (0.158) |
2.29 (0.162) |
|
|
| |
Week 4 |
2.15 (0.154) |
2.09 (0.160) |
0.06 (0.223) |
0.797 |
| |
Week 8 |
2.08 (0.166) |
1.87 (0.175) |
0.21 (0.242) |
0.384 |
| Overall symptom severity |
Baseline |
2.54 (0.149) |
2.66 (0.153) |
|
|
| |
Week 4 |
2.44 (0.171) |
2.07 (0.178) |
0.37 (0.248) |
0.134 |
| Week 8 | 2.20 (0.165) | 1.82 (0.174) | 0.38 (0.241) | 0.114 | |
1 Symptom severity scoring scale: 0, none; 1, very mild; 2, mild; 3, moderate; 4, severe; 5, very severe