Table 3. Comparison of two pairwise strategies, MAX and BMA, on estimating the functional conservation between human-mouse orthologs using Z-score analysis.

	Including IEA			Excluding IEA
	BP	CC	MF	BP	CC	MF
HRSS	815.28	136.27	345.35	329.13	47.26	180.37
Resnik	94.43	57.75	67.31	51.75	6.03	37.55
Jiang	250.30	105.12	145.45	196.93	55.78	62.00
Lin	160.04	92.19	124.88	106.04	50.85	49.37
RSS	99.84	52.58	93.95	42.95	22.01	37.65

The difference between the two approaches was measured by the Z-score of the BMA approach minus the Z-score of MAX. This table showed a higher functional conservation of human-mouse orthologs statistically using the BMA approach.