Table 1. Correlation and Multivariate Linear Regression Analyses.

Correlations between ADI-R scores for the three domains: social behavior, communication, and repetitive behavior, and cytokine concentrations are shown in (A). The first row is the Pearson’s correlation coefficient, the second row is the p-value for the test of the Pearson’s r, and the third row is the number of observations. Higher ADI-R scores indicate greater social impairments, greater communication impairments, or the presence of more severe or more frequent repetitive behavior. Multivariate linear regression model of the ADI-R scores for social behavior (B) and repetitive behavior (C) are also shown. The ADI-R social score assesses qualitative abnormalities in reciprocal social interaction; while the repetitive score assesses restricted, repetitive, and stereotyped patterns of behavior.

A.
	ln IL-6	IL-12p70	ln INFγ	ln IL-1β	In IL-8	ln TNFα	ln IL-10
Social	0.408	0.296	-0 170	0 851*	0 441	0.466	−0.180
	0.117	0.325	0.661	0.004	0.088	0.069	0.504
	16	13	9	9	16	16	16
Repetitive	0.2	0.774*	0 795*	0.336	0 380	0.369	−0.1 S2
	0.457	0.002	0.033	0.376	0.147	016	0499
	16	13	7	9	16	16	16
Communication	0.323	0.477	−0.773	0.663	0.235	0.23	0.031
	0.751	0.117	0.125	0.151	0439	0.451	0.919
	13	12	5	6	13	13	13

	ln IL-6:IL-10	ln IL-12p:IL-10	ln INFγ IL-10	ln IL-1β: IL-10	In IL-8:IL-10	In TNFα:IL-10
Social	0.580*	0.305	−0.125	0.690*	0.492	0.486
	0.018	0.312	0.749	0.040	0.053	0.056
	16	13	9	9	16	16
Repetitive	0.351	0.563*	0.48	0.305	0.433	0.43
	0.183	0.045	0.191	0.425	0.094	0.097
	16	13	9	9	16	16
Communication	0.376	0.217	−0.146	0.109	0.171	0.111
	0.205	0.499	0.755	0.837	0.718	0.718
	13	12	7	6	13	13

B. Social Behavior Score on ADI-R
Effect	Estimate	Standard Error	P value
Age (years)	0.106	0.227	0.649
Sex	−1.545	3.731	0.686
ln IL-6:IL-10	4.52	1.954	0.039

C. Repetitive Behavior Score on ADI-R
Effect	Estimate	Standard Error	P value
Age (years)	−0.241	0.229	0.0003
Sex	0.811	0.61	0.22
IL-12p70	3.237	0.406	<.0001
ln IL-10	−1.182	0.502	0.0467

^*= p < 0.05