Table 1. Baseline demographics for cohort.
| CKD (32) | PD (16) | HD (40) | Sig. | |
| Age (years) | 62±12 | 63±11 | 59±15 | ns |
| Male | 17 (53%) | 8 (50%) | 27 (68%) | ns |
| Diabetes mellitus | 5 (16%) | 4 (25%) | 10 (25) | ns |
| Smoking | 4 (13%) | 1 (6%) | 5 (13%) | ns |
| Dialysis vintage (months) | - | 33±22 | 38±25 | ns |
| BMI (kg/m2) | 27±6 | 25±3 | 27±5 | ns |
| Urea (mmol/l) | 23±8 | 21±5 | 19±4 | 0.02, 0.01** |
| eGFR (MDRD) (ml/min) | 16±5 | - | - | n/a |
| Dialysis adequacy (Kt/V)a | - | 2.44±0.52 | 1.25±0.35 | n/a |
| Previous CV morbidityb | 8 (25%) | 6 (38%) | 7 (18%) | ns |
| Total cholesterol (mmol/l) | 5.2±0.9 | 4.6±1.0 | 4.4±1.0 | 0.002, ns*,***, 0.02** |
| HDL cholesterol (mmol/l) | 1.4±0.3 | 1.4±0.3 | 1.3±0.3 | ns |
| LDL cholesterol (mmol/l) | 2.8±1.1 | 2.8±1.1 | 2.0±0.8 | 0.008, ns*,***, 0.012** |
| Triglycerides | 1.9±1.2 | 2.2±0.8 | 2.4±1.8 | ns |
| Serum phosphate (mmol/l) | 1.46±0.3 | 1.58±0.2 | 1.73±0.4 | 0.005, ns*,***, 0.03** |
| Serum corrected calcium (mmol/l) | 2.40±0.1 | 2.54±0.1 | 2.47±0.1 | 0.001, 0.01*, ns**,*** |
| Calcium×Phosphate product (mmol2/l2) | 3.50±0.7 | 4.01±0.7 | 4.28±1.0 | 0.001, ns*,***, 0.001** |
| PTH (pg/ml) | 185±103 | 362±333 | 305±318 | ns |
| Albumin (g/l) | 34±3 | 28±3 | 34±3 | <0.001, <0.001*,***, ns** |
| High-sensitivity C-reactive protein (mg/l) | 4.11±5.9 | 4.02±4.7 | 8.24±10 | ns |
| Bicarbonate (mmol/l) | 23±4 | 27±3 | 23±3 | <0.001, 0.002*, ns**, 0.001*** |
| Use of Vitamin D | 10 (31%) | 11 (69%) | 22 (55%) | 0.026 |
| Lipid lowering therapy | 11 (34%) | 7 (44%) | 13 (33%) | ns |
| Use of non-Calcium containing binders | 1 (3%) | 10 (63%) | 20 (50%) | <0.001 |
| Use of Calcium containing binders | 13 (41%) | 6 (38%) | 25 (63%) | ns |
| Use of Calcium channel blockers | 13 (41%) | 5 (31%) | 12 (30%) | ns |
| Use of ACE inhibitors | 15 (47%) | 7 (44%) | 6 (15%) | 0.006 |
| Use of Beta blockers | 13 (41%) | 2 (13%) | 12 (30%) | ns |
| Use of Epo | 7 (22%) | 13 (81%) | 38 (95%) | <0.001 |
Results are mean ± SD or number of observations (percentage) for categorical data.
Key/Notes :
ns – not significant.
*
– comparison CKD vs PD.
**
– comparison CKD vs HD.
***
– comparison PD vs HD.
a
– Kt/V is Weekly in PD, per session in HD.
b
– defined as any previous description of ischaemic heart disease, heart failure, cerebrovascular disease or peripheral vascular disease.