Table 1. Immunofluorescence analysis of simple keratin expression in K7 knockout mice.
Tissue | K7 expression | K8 | K18 | K19 | K20 |
Bladder | Urothelium | = | reduced* | = | = |
Liver | Bile ducts | = | = | = | ne. |
Colon | Basal cells in crypts, goblet cells | = | = | = | = |
Kidney | Collecting tubules & ducts | = | reduced | = | ne. |
Lung | Alveolar & bronchiolar epithelium | = | = | = | ne. |
Pancreas | Ductal epithelial cells | = | = | = | ne. |
Duodenum | Brunner’s gland & specific cells in crypt | = | = | = | = |
Stomach | Squamo-columnar cells | = ¶ | = ¶ | = ¶ | = ¶ |
= intensity of staining and localization similar to wildtype tissue.
confirmation by western blotting.
ne. no protein expression.
glandular cell staining.