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. 2013 May 31;8(5):e63591. doi: 10.1371/journal.pone.0063591

Table 4. Sensitivity analysis to evaluate the effect of trial design on percentage IOP reduction.

Studies (n) WMD(Random) (95%CI) Heterogeneity Overall effect
Q P I 2 (%) Z P
All trials 7 2.33(−2.59,7.24) 2.25 0.90 0.00% 0.93 0.35
Retro 3 2.67(−5.04,10.38) 0.80 0.67 0.00% 0.68 0.50
Pro 2 1.18(−6.55,8.90) 0.85 0.36 0.00% 0.30 0.77
RCT 2 4.06(−7.25,15.37) 0.41 0.52 0.00% 0.70 0.48

CI  =  confidence interval; IOP  =  intraocular pressure; RCT  =  prospective randomized controlled trial; Retro  =  retrospective; Pro  =  prospective nonrandomized; WMD  =  weighted mean difference.