Table 1. Selected calcitriol-regulated genes involved in axogenesis and myelination.
DRG/SC Fold Change | Gene Symbol | Gene Name | SC Fold Change |
1.6 | Acsl4 | Acyl-CoA synthetase 4 | 1.7 |
Adm | Adrenomedullin | 2.3 | |
1.55 | Agtr1a | Angiotensin II receptor 1a | 1.6 |
Aqp1 | Aquaporin 1 | 1.75 | |
-2.6 | Cdh2 | Cadherin 2 | |
1.5 | Cdw92 | Solute carrier family 44, member 1 | |
-3.6 | Chl1 | Cell adhesion molecule with homology to L1CAM | |
Cacna1b | Calcium channel, voltage-dependent, Nalpha1B | -2.5 | |
Clcf1 | Cardiotrophin-like cytokine factor 1 | 3.1 | |
Crlf1 | Cytokine receptor-like factor 1 | 1.8 | |
Cxcl12 | Chemokine 12 | 1.9 | |
Clu | Clusterin | 2.3 | |
Got1 | Glutamic-oxaloacetic transaminase 1 | 2 | |
Igf1 | Insulin-like growth factor 1 | 2.4 | |
Klhl24 | Kainate receptor-interacting protein for GluR6 | 1.7 | |
1.8 | Kras | Kirsten rat sarcoma viral oncogene homolog | |
1.9 | Limk1 | LIM domain kinase 1 | |
-2.9 | Map1b | Microtubule-associated protein 1B | |
Mapk8ip1 | Mitogen-activated protein kinase 8 interact prot 1 | 1.8 | |
Metrn | Meteorin | 1.8 | |
1.7 | Myc | V-myc myelocytomatosis viral oncogene | |
-5.7 | Mycbp2 | MYC binding protein 2 | |
1.6 | Ncam1 | Neural cell adhesion molecule 1 | |
Ndrg2 | NDRG family member 2 | 1.9 | |
Nefm | Neurofilament, medium polypeptide | -3.9 | |
1.9 | Ppp3cb | Protein phosphatase 3, catalytic subunit, beta | |
3.5 | Ppp3r1 | Protein phosphatase 3, regulatory subunit B alpha | |
2 | Prx | Periaxin | |
-2.1 | Rbpj | Rec signal binding prot for IgK J region | |
1.6 | Rcan1 | Regulator of calcineurin 1 | |
1.7 | Rhoa | Ras homolog gene family, member A | |
Rtn4rl2 | Nogo receptor-like 3 | -2.1 | |
1.6 | Ryk | Receptor-like tyrosine kinase | |
2.2 | Spp1 | Osteopontin | 4 |
1.6 | Strn3 | Striatin, calmodulin binding protein 3 | |
Thbs4 | Thrombospondin 4 | 2.5 | |
1.5 | Trim2 | Tripartite motif-containing 2 | |
Tspan2 | Tetraspanin 2 | 1.8 | |
1.5 | Ulk2 | Unc-51 like kinase 2 | |
Vegfa | Vascular endothelial growth factor A | 1.9 |
Selected list of transcripts, involved in axogenesis and myelination, whose expression is modified after the addition of calcitriol (100 nM), during 24 hours, to cultures of Schwann cells (SC) or co-cultures of DRG and SC. The symbol, the full name and the fold change of each gene are indicated. Under-expressed genes are in italic. Calcitriol-regulated genes in both Schwann cell and DRG/Schwann cell cultures are in bold.