Table 1. Relationship of Power to Independent Non-Causal and Causal SNPs^1,2.

Gene-Based Test	Estimated absolute power loss for one additional non-causal SNP#	Estimated absolute power gain for one additional causal SNP	Estimated number of non-causal SNPs which cancel out the power gained from one causal SNP
GATES	0.0025	0.0160	6.3
VEGAS-SUM	0.0028	0.0299	10.6
VEGAS-MAX	0.0025	0.0151	6.1
LR-PC	0.0023	0.0267	11.5
LR	0.0027	0.0305	11.4

¹Using a multiple regression model including all parameter and simulation results.

²Assuming all other parameters are held constant.