Table 2. Cardiac morphological parameters in Ctrl and Dox-CM rats, at d35 and d70.
d35 | d70 | |||
Parameters | Ctrl(n = 30) | Dox-CM (n = 34) | Ctrl (n = 12) | Dox-CM (n = 10) |
Body wt (g) | 516±7 | 395±6** | 571±19 | 341±22** |
Heart wt (mg) | 1445±31 | 1112±17** | 1317±24 | 879±51** |
LV wt (mg) | 729±17 | 562±11** | 755±16 | 483±28** |
Heart wt/Body wt (mg.g−1) | 2.80±0.03 | 2.82±0.04 | 2.32±0.04 | 2.60±0.07* |
LV wt/Body wt (mg.g−1) | 1.41±0.02 | 1.43±0.02 | 1.33±0.04 | 1.43±0.05 |
Heart wt/Tibia length (mg.cm−1) | 272±5 | 218±3** | 239±4 | 166±9** |
LV wt/Tibia length (mg.cm−1) | 137±3 | 110±2** | 137±3 | 92±5** |
Ctrl: control; Dox-CM: Doxorubicin-induced cardiomyopathy; LV: left ventricle; wt: weight. Values are means ± sem. *: P<0.05 vs respective Ctrl. **: P<0.001 vs respective Ctrl.