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. 2013 Jun;98(6):888–895. doi: 10.3324/haematol.2012.078055

Figure 3.

Figure 3.

Secreted factors from unstimulated MSC are responsible for the inhibition of monocyte differentiation. Monocytes were differentiated in the presence of different conditioned media. (A) Representative dotplots of monocytes differentiated for 6 days in the presence of various conditioned media. (B) Cumulative data of CD1a and CD14 expression on day 6 monocytes differentiated in the presence of various conditioned media (data were collected from two different MSC donors and one monocyte donor). MSC-CM, MSC conditioned medium; MSC+GF CM, conditioned medium from MSC cultures containing the growth factors IL-4 and GM-CSF; MSC+mono CM, conditioned medium from the monocytes differentiated with growth factors in the presence of MSC in a direct co-culture. Statistical significance is compared to control (*P<0.05,**P<0.01).