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. 2013 Jun;98(6):918–927. doi: 10.3324/haematol.2012.074195

Figure 4.

Figure 4.

Menin promotes EZH2 expression in MA9 cells. (A) Real-time PCR analysis of Mecom and Ezh2 transcript levels in control or Men1-excised AT-1 cells 6 days after 4-OHT treatment. (B) Western blot for EZH2 in control or Men1-excised AT-1 cells 6 days after 4-OHT treatment. (C–D) ChIP assays for menin, AF9c (C), and MLL-C (D) binding at the Ezh2 promoter in control or Men1-excised AT-1 cells 6 days after 4-OHT treatment. (E) ChIP assays for H3K4m3 and H3K79m2 at the Ezh2 promoter 6 days after 4-OHT treatment.