Table 1.
Summary of ESSEA locations, enrollment numbers, and methodologies
| Status | Country | Principal Investigator(s) | Project title | Current N | Total N | Topic key words | Risk Groups | Methodology/technologies | Project start |
|---|---|---|---|---|---|---|---|---|---|
| Ongoing full-scale | UK | M. H. Johnson | British Autism Study of Infant Siblings (BASIS)-UK research network www.basisnetwork.org | 188 | 260 | Brain, social, attention, motor, BAP, genetics, intervention | Infant ASD siblings | Genetics, EEG, ERP, MRI, DTI, NIRS, behavior, eye tracking, standardized measures, questionnaires | 2008 |
| Belgium | H. Roeyers | Social cognitive mechanisms of understanding intentional agents in typical and atypical development | 60 | 150 | Social development, attention | Infant ASD siblings | EEG, ERP, behavior, eye tracking, standardized measures, questionnaires | 2007 | |
| 0 | 100 | Preterm infants | 2012 | ||||||
| Sweden |
U. Ådén B. Vollmer S. Bölte |
Follow up of extremely preterm infants at 6 years—a population-based study in Stockholm (NeoBIC) | 50 | 117 | Brain, cognition | Preterm infants | Standardized measures, questionnaire, MRI | 2004 | |
| Sweden |
S. Bölte T. Falck-Ytter G. Gredebäck |
Early Autism Sweden (EASE) www.earlyautism.se | 30 | 100 | Non-verbal communication, BAP, autonomous system, motor function, brain, microbiota | Infant ASD siblings | Eye tracking, MRI, DTI, EEG/ERP, behavior, standardized measures questionnaires | 2011 | |
| 0 | 30 | Infants with fetal alcohol/neonatal abstinence syndrome | TBD | ||||||
| Italy | T. Farroni | Predictors at birth and in premature babies | 3 | TBD | ASD predictors | Preterm infants | NIRS, behavioral | 2010 | |
| Pilot | Czech Republic | M. Hrdlicka | New approaches to early diagnostics of autism | 5 | 12 | Genetics | ASD siblings | Karyotyping, screening, CNV analysis | 2011 |
| Israel | N. Yirmiya | Association between preterm birth and ASD spectrum disorders and the BAP | 25 | 100 | ASD phenotype | Preterm infants | Observation, interview | 2009 | |
| Israel | D. Mankuta | Prenatal clues for Autism in high-risk groups | 35 | 300 | Biochemical, sonographic, genetic markers | Infant ASD siblings | Ultrasound, amniotic fluid analyses | 2012 | |
| Planned | Portugal | A. Vicente | Earliest signs of autism | 0 | 200 | Genetics | TBD | CGH arrays, questionnaires | 2012 |
| Spain |
M. Posada R. Canal |
Spanish ASD sibling cohort: feasibility study | 0 | TBD | Feasibility, epidemiology | Infant ASD siblings | Screening | 2011 |
TBD to be determined, BAP broader autism phenotype