Table 2.
Differentiation of continuous Ki-67 percentages by analysis of variance (ANOVA)
| Characteristic | Absolute Ki-67 mean (±SD) | Total n | P value a |
|---|---|---|---|
| Menopausal status | |||
| Premenopausal | 24.1 (±20.4) | 805 | <0.001 |
| Postmenopausal | 19.3 (±17.3) | 2,853 | |
| Tumor size | |||
| pT1 | 17.7 (±16.3) | 1,955 | <0.001 |
| pT2 | 24.1 (±20.3) | 1,283 | |
| pT3 | 20.7 (±15.7) | 133 | |
| pT4 | 20.1 (±16.6) | 149 | |
| Nodal status | |||
| N0 | 18.9 (±17.9) | 2,146 | <0.001 |
| N1 | 21.6 (±18.6) | 811 | |
| N2 | 23.4 (±17.9) | 277 | |
| N3 | 24.4 (±17.0) | 208 | |
| Histology | |||
| Ductal | 21.8 (±18.7) | 3,013 | <0.001 |
| Lobular | 13.3 (±10.7) | 426 | |
| Other | 14.5 (±17.5) | 219 | |
| Grading | |||
| G1 | 9.7 (±8.2) | 664 | <0.001 |
| G2 | 16.2 (±12.7) | 2,064 | |
| G3 | 37.4 (±22.1) | 913 | |
| Lymphatic invasion | |||
| L0 | 18.2 (±17.3) | 2,202 | <0.001 |
| L1 | 24.3 (±18.9) | 1,180 | |
| Vascular invasion | |||
| V0 | 19.7 (±17.9) | 3,111 | <0.001 |
| V1 | 27.8 (±19.9) | 210 | |
| Estrogen receptor | |||
| Positive | 16.8 (±14.1) | 3,137 | <0.001 |
| Negative | 41.9 (±24.0) | 518 | |
| Progesterone receptor | |||
| Positive | 16.5 (±13.8) | 2,823 | <0.001 |
| Negative | 33.5 (±24.1) | 832 | |
| HER2/neu | |||
| Positive | 27.5 (±19.0) | 657 | <0.001 |
| Negative | 18.7 (±17.5) | 2,961 | |
| Receptor status | |||
| ER+ PR+ | 16.1 (±13.2) | 2,787 | <0.001 |
| ER+ PR− | 21.9 (±19.1) | 350 | |
| ER− PR+ | 40.6 (±27.4) | 31 | |
| ER− PR− | 41.9 (±23.8) | 487 | |
a P value for ANOVA