Table 3.

Association of Ki-67 with clinical and histopathological parameters in univariable analysis

Characteristic	Disease-free survival			Overall survival
	HR	95 % CI	P ≤	HR	95 % CI	P ≤
Age (n = 3,658)	1.05	1.05–1.06	0.001	1.07	1.06–1.08	0.001
Ki-67-categories (%) (n = 3,658)
≤15	1			1
16–25	1.24	0.95–1.61	0.11	1.26	0.94–1.69	0.12
26–35	2.02	1.52–2.69	0.001	2.12	1.55–2.90	0.001
36–45	2.00	1.34–2.98	0.001	2.12	1.37–3.26	0.001
>45	2.42	1.87–3.15	0.001	2.13	1.58–2.88	0.001
Menopausal status (n = 3,658)
Premenopausal	1			1
Postmenopausal	2.19	1.64–2.93	0.001	3.20	2.20–4.66	0.001
Tumor size (n = 3,520)
pT1	1			1
pT2	2.99	2.35–3.80	0.001	3.08	2.33–4.05	0.001
pT3	5.80	3.92–8.59	0.001	5.77	3.70–9.02	0.001
pT4	7.68	5.46–10.80	0.001	9.44	6.52–13.66	0.001
Nodal status (n = 3,442)
N0	1			1
N1	2.20	1.71–2.83	0.001	2.01	1.51–2.69	0.001
N2	3.23	2.34–4.46	0.001	2.92	2.02–4.23	0.001
N3	4.39	3.19–6.05	0.001	4.05	2.82–5.83	0.001
Histology (n = 3,658)
Ductal	1			1
Lobular	0.99	0.74–1.32	0.94	1.01	0.73–1.40	0.935
Other	0.72	0.46–1.13	0.15	0.87	0.55–1.39	0.568
Grading (n = 3,641)
G1	1			1
G2	3.05	2.05–4.55	0.001	2.64	1.74–4.00	0.001
G3	5.00	3.33–7.50	0.001	4.04	2.63–6.19	0.001
Lymphatic invasion (n = 3,382)
L0	1			1
L1	2.55	2.07–3.14	0.001	2.31	1.83–2.92	0.001
Vascular invasion (n = 3,321)
V0	1			1
V1	3.27	2.49–4.29	0.001	2.72	1.98–3.75	0.001
Estrogen receptor (n = 3,655)
Positive	1			1
Negative	2.22	1.80–2.75	0.001	2.23	1.76–2.82	0.001
Progesterone receptor (n = 3,655)
Positive	1			1
Negative	2.18	1.80–2.65	0.001	2.14	1.72–2.66	0.001
HER2/neu (n = 3,618)
Negative	1			1
Positive	1.39	1.12–1.74	0.003	1.23	0.96–1.59	0.106
Receptor status (n = 3,655)
ER+ PR+	1			1
ER+ PR–	1.86	1.40–2.47	0.001	1.79	1.30–2.47	0.001
ER− PR+	1.95	0.81–4.73	0.138	2.01	0.75–5.40	0.167
ER− PR−	2.45	1.96–3.07	0.001	2.44	1.90–3.13	0.001