Table 4.

Association of Ki-67 with clinical and histopathological parameters in multivariable analysis (n = 3,174 due to occasional missing values)

Characteristic	Disease-free survival			Overall survival
	HR	95 % CI	P ≤	HR	95 % CI	P ≤
Age	1.05	1.04–1.07	0.001	1.07	1.06–1.09	0.001
Ki-67-categories (%) (n = 3,174)
≤15	1			1
16–25	1.00	0.72–1.39	1.00	1.14	0.78–1.66	0.49
26–35	1.44	0.97–2.12	0.07	1.71	1.10–2.65	0.017
36–45	1.50	0.91–2.48	0.11	2.05	1.18–3.55	0.011
>45	1.96	1.31–2.91	0.001	2.06	1.30–3.28	0.002
Menopausal status
Premenopausal	1			1
Postmenopausal	0.62	0.39–0.98	0.041	0.62	0.35–1.10	0.11
Tumor size
pT1	1			1
pT2	1.52	1.14–2.02	0.003	1.52	1.09–2.12	0.017
pT3	1.97	1.21–3.19	0.008	2.03	1.16–3.56	0.013
pT4	2.04	1.29–3.21	0.003	2.24	1.36–3.70	0.002
Nodal status
N0	1			1
N1	1.38	1.03–1.87	0.034	1.31	0.93–1.86	0.12
N2	1.88	1.29–2.74	0.001	1.97	1.28–3.04	0.002
N3	2.12	1.44–3.14	0.001	2.28	1.46–3.57	0.001
Histology
Ductal	1			1
Lobular	1.22	0.86–1.73	0.26	1.23	0.82–1.84	0.32
Other	0.94	0.52–1.70	0.83	1.05	0.56–1.97	0.89
Grading
G1	1			1
G2	1.88	1.14–3.09	0.013	1.62	0.95–2.80	0.08
G3	1.96	1.12–3.41	0.018	1.46	0.79–2.67	0.23
Lymphatic invasion
L0	1			1
L1	1.20	0.91–1.59	0.20	1.04	0.75–1.43	0.82
Vascular invasion
V0	1			1
V1	1.44	1.04–2.01	0.030	1.28	0.87–1.89	0.21
Estrogen receptor
Positive	1			1
Negative	1.41	0.97–2.06	0.073	1.85	1.19–2.89	0.007
Progesterone receptor
Positive	1			1
Negative	1.39	0.99–1.95	0.056	1.29	0.87–1.93	0.21
HER2/neu
Negative	1			1
Positive	0.86	0.65–1.14	0.28	0.70	0.80–0.98	0.036