Figure 6.

Total vitreal delivery decreases, whereas choroid–RPE and retinal delivery increases with increase in solute lipophilicity after suprachoroidal injection. Effect of beta-blocker lipophilicity on (A) choroid–RPE, (C) retina, and (E) vitreous delivery in ex vivo albino rabbit eyes after suprachoroidal injection is shown. Beta-blocker lipophilicity showed a direct linear correlation with (B) choroid–RPE and (D) retinal levels and an inverse correlation with (F) vitreal levels. Data represent mean±standard deviation for n=4. * means the value is significantly different from atenolol, sotalol, nadolol, and pindolol at p≤0.05