FIG. 5.

Fundus photographs of DNR-loaded hydrosilylated pSi particles (A, B) and empty hydrosilylated pSi particles (C, D) in the rabbit eyes. Focus of the images was on the particles instead of on the retina. The photograph (A) shows DNR-loaded particles in the vitreous 1 week after intravitreal injection (arrow), (B) demonstrates a reduction in the amount of particles after 3 months in the same eye, but the color was barely changed (arrow), indicating simultaneous particle degradation and drug release. (C) shows the typical bright vivid color of empty pSi (arrow) taken at 2 months with a major change of amount and color after 6 months (D) and the degraded pSi looked whitish and dull (arrow). Color images available online at www.liebertpub.com/jop