Table 2.
Clinicopathological characteristics based on hENT1, dCK, and RRM1 expression for advanced biliary tract cancer subjects
| Characteristic | hENT1 expression | P value | dCK expression | P value | RRM1 expression | P value | |||
|---|---|---|---|---|---|---|---|---|---|
| |
Low (n = 11) |
High (n = 17) |
|
Low (n = 13) |
High (n = 15) |
|
Low (n = 11) |
High (n = 17) |
|
| Primary tumor site |
|
|
|
|
|
|
|
|
|
| Extrahepatic bile duct |
7 |
11 |
1.000 |
10 |
8 |
0.254 |
8 |
10 |
0.689 |
| Gallbladder |
4 |
6 |
|
3 |
7 |
|
3 |
7 |
|
| Recurrence or unresectable |
|
|
|
|
|
|
|
|
|
| Recurrence after surgery |
9 |
13 |
1.000 |
9 |
13 |
0.372 |
7 |
15 |
0.174 |
| Unresectable |
2 |
4 |
|
4 |
2 |
|
4 |
2 |
|
| Histological type |
|
|
|
|
|
|
|
|
|
| Well/moderately |
9 |
12 |
0.668 |
11 |
10 |
0.396 |
9 |
12 |
0.668 |
| Poor |
2 |
5 |
|
2 |
5 |
|
2 |
5 |
|
| hENT1 expression |
|
|
|
|
|
|
|
|
|
| High |
– |
– |
– |
7 |
10 |
0.700 |
6 |
11 |
0.701 |
| Low |
– |
– |
|
6 |
5 |
|
5 |
6 |
|
| dCK expression |
|
|
|
|
|
|
|
|
|
| High |
* |
* |
* |
– |
– |
– |
2 |
13 |
0.006 |
| Low | * | * | – | – | 9 | 4 | |||
dCK, deoxycytidine kinase; hENT1, human equilibrative nucleoside transporter; RRM1, ribonucleotide reductase subunit M1. *Same as above line (hENT1 expression).