Table 5.
Multivariate analysis for overall survival using variables including hENT1 and RRM1
| Variable | Comparison | HR | 95% CI | P value |
|---|---|---|---|---|
| Primary tumor site |
Gallbladder vs. extrahepatic bile duct |
2.136 |
0.751 to 6.078 |
0.155 |
| Recurrence or unresectable |
Unresectable vs. recurrence |
3.109 |
0.860 to 11.238 |
0.084 |
| Histological type |
Poor vs. well/moderately |
0.732 |
0.235 to 2.282 |
0.591 |
| hENT1 expression |
High vs. low |
0.220 |
0.077 to 0.629 |
0.005 |
| RRM1 expression | High vs. low | 2.315 | 0.773 to 6.928 | 0.133 |
CI, confidence interval; hENT1, human equilibrative nucleoside transporter; HR, hazard ratio; RRM1, ribonucleotide reductase subunit M1.