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Diverse actions of NO in cancer: tumoricidal role of NO
|
Tumoricidal role | |
|---|---|
| Role of NO | Mechanism by which NO acts |
| Cytostatic and\or cytotoxic effect on tumor cells | NO suppresses cellular respiration and also shifts iron metabolism |
| Suppression of DNA synthesis | |
| Proapoptotic modulator by activating caspase family proteases, upregulation of p53, alteration in expression of apoptosis-associated proteins | |
