Table 3.
Medication discontinuation, hospitalization patterns and concomitant medication utilization in RLAI* and FGAI treatment groups
| Outcome | RLAI (n = 70) | FGAI (n = 102) | P value |
|---|---|---|---|
|
Discontinuation |
|
|
|
| Proportion of patients discontinued (n (%)) |
11 (15.7) |
13 (12.7) |
0.30 |
| Mean time to discontinuation (Months ± SD) |
7.2 ± 5.4 |
7.9 ± 4.8 |
0.99 |
| Reason for discontinuation (n (%)) |
|
|
|
| Patient choice |
7 (63.6) |
5 (38.5) |
0.22 |
| Intolerability |
2 (18.2) |
4 (30.8) |
0.65 |
| Treatment failure |
2 (18.2) |
0 (0) |
0.20 |
| Unknown |
0 (0) |
4 (30.8) |
0.49 |
|
Hospitalization |
|
|
|
| Proportion of patients hospitalized (n (%)) |
10 (14.3) |
13 (12.7) |
0.09 |
| Mean time to hospitalization (Months ± SD) |
5.4 ± 2.8 |
5.8 ± 5.1 |
0.80 |
| Mean duration of hospitalization (Days ± SD) |
35 ± 24 |
29 ± 17 |
0.49 |
| Reason for hospitalization (n (%)) |
|
|
|
| Treatment failure |
10 (100) |
13 (100) |
1.00 |
|
Concomitant medications (n (%)) |
|
|
|
| Additional antipsychotic |
21 (30) |
42 (41.1) |
0.14 |
| Anticholinergic |
4 (5.7) |
36 (35.3) |
<0.001 |
| Mood stabilizer |
13 (18.6) |
11 (10.8) |
0.15 |
| Antidepressant |
10 (14.3) |
26 (25.5) |
0.08 |
| Benzodiazepine | 7 (10.0) | 9 (8.8) | 0.79 |
*Abbreviations are; RLAI Risperidone long-acting injection, FGAI First generation antipsychotic injection, SD standard deviation.