Table III.
Amount of new bone, fibrous tissue, and bone marrow-like tissue formed in bioactive glass (13-93) scaffolds implanted for 6 weeks in rat calvarial defects. The amount of each tissue is expressed as a percent of the available pore space (area) in the scaffolds and the total defect area.
Scaffold group | New bone (%)
|
Fibrous tissue (%)
|
Bone marrow-like tissue (%)
|
|||
---|---|---|---|---|---|---|
Available area | Total area | Available pore area | Total area | Available area | Total area | |
As fabricated (0d) | 32 ± 13 | 18 ± 8 | 62 ± 14 | 34 ± 8 | 1 ± 1 | 1 ± 1 |
1d | 46 ± 10 | 25 ± 5 | 45 ± 12 | 25 ± 7 | 2 ± 1 | 1 ± 1 |
3d | 57 ± 14 | 33 ± 10 | 35 ± 13 | 19 ± 7 | 3 ± 2 | 2 ± 1 |
6d | 45 ± 11 | 26 ± 8 | 48 ± 13 | 28 ± 8 | 2 ± 1 | 1 ± 1 |
1d+BMP | 65 ± 7 | 38 ± 4 | 14 ± 12 | 8 ± 7 | 13 ± 6 | 8 ± 3 |
3d+BMP | 61± 8 | 35 ± 3 | 7 ± 7 | 4 ± 4 | 22 ± 8 | 12 ± 4 |
6d+BMP | 64 ± 11 | 38 ± 6 | 15 ± 19 | 10 ± 12 | 16 ± 8 | 10 ± 5 |