Table 1.
Drug sensitivity of BCap37, Bads-200 and Bats-72
Drug | BCap37 |
Bads-200 |
Bats-72 |
||
---|---|---|---|---|---|
IC50 * (nM) | IC50 (nM) | RI** | IC50 (nM) | RI | |
Paclitaxel | 4 ± 1.2 | 4550 ± 340 | 1138 | 454 ± 65 | 113.5 |
Docetaxel | 2.7 ± 0.4 | 1680 ± 80 | 622.2 | 248 ± 38 | 91.9 |
Vinorelbine | 20 ± 3.4 | 1850 ± 160 | 92.5 | 1040 ± 180 | 52 |
Doxorubicin | 270 ± 26 | 9950 ± 650 | 36.9 | 5600 ± 240 | 20.7 |
Etoposide | 12300 ± 800 | 79000 ± 5200 | 6.4 | 59100 ± 3300 | 4.8 |
Gemcitabine | 418 ± 36 | 482 ± 63 | 1.2 | 1400 ± 90 | 3.4 |
Methotrexate | 18.6 ± 3.9 | 19.6 ± 7.4 | 1.1 | 39.5 ± 5.8 | 2.12 |
5-flourouracil | 15200 ± 1200 | 22400 ± 1800 | 1.5 | 25800 ± 2300 | 1.7 |
Cisplatin | 1550 ± 240 | 1220 ± 210 | 0.79 | 1500 ± 170 | 0.97 |
The IC50 values were defined as the concentration of cells inhibiting growth at 50%.
Drug resistance index (RI) was determined by deviding IC50 values of Bads-200 or Bats-72 by that of BCap37 cells.