Deletion of HNF4α using TAM (TAM) driven albumin cre mice. (A) Scheme of HNF4α deletion using the HNF4αFl/Fl, AlbERT2-Cre+ mice. (B) Western blot analysis of HNF4α using nuclear proteins isolated from HNF4αFl/Fl, AlbERT2-Cre+ mice treated with either TAM or corn oil and HNF4αFl/Fl, AlbERT2-Cre− mice treated TAM. See Methods section for details. (C) Liver weight to body weight ratios (D) serum ALT levels, and (E) serum glucose levels of Control, HNF4α-KO and TAM Control mice seven days after either TAM or corn oil injection.