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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: NMR Biomed. 2013 Jan 28;26(7):803–809. doi: 10.1002/nbm.2907

Figure 2. Modulations in the BOLD fMRI responses in the rat’s primary somatosensory cortex (S1) induced by optogenetics stimulation.

Figure 2

a. Examples of BOLD fMRI activation z-maps (p<0.05) induced by sensory (contralateral forepaw) and ChR2 stimulation overlaid on the EPI images. The optic fiber was placed directly above the right S1. The time courses of BOLD fMRI responses across the different cortical laminae are shown. b. Light induced activation of eNpHR resulted in decreases in both the extent and the amplitude of BOLD fMRI responses during forepaw stimulation mainly in the upper cortical laminae. Z statistic activation maps (p<0.05) are overlaid on RARE anatomical images. Red bars represent forepaw stimulation. Images were acquired using a Bruker 9.4 T animal dedicated scanner.