. Author manuscript; available in PMC: 2014 Mar 13.

Published in final edited form as: Biochemistry. 2013 Feb 27;52(10):10.1021/bi301722k. doi: 10.1021/bi301722k

Table 1.

EC₅₀ (nM) values for reporter gene induction by TCDD and FICZ in COS-7 cells transfected with mouse or frog AHRs bearing the indicated mutations.

	AHR1β	N325S	A354S	A370S	A354S/N325S	chimera	mouse
TCDD	18.6 ± 4.7^a	5.7 ± 1.6	1.2 ± 0.4	1.0± 0.4	0.82± 0.42	0.20 ± 0.10	0.50± 0.16
(24 hr)
FICZ	0.08 ±	0.07 ±	0.04 ±	0.04 ±		0.03 ± 0.01
	0.02	0.02	0.01	0.01
(3 hr)

Values represent mean ± standard error for 3-9 replicates.