. Author manuscript; available in PMC: 2014 Mar 13.

Published in final edited form as: Biochemistry. 2013 Feb 27;52(10):10.1021/bi301722k. doi: 10.1021/bi301722k

Table 2.

EC₅₀ (nM) values for reporter gene induction by TCDD. COS-7 cells were transfected with mouse or frog AHRs bearing the indicated mutations. Standard error is indicated for each mean. n=3-4 for each AHR (except where indicated)

	T256A	S263P	T256A/S263P	S371T	S294Q	KHSR^b
TCDD	23.1 ±	23.7 ±8.8	20.6 ± 8.0	13.5 ±3.3	25.9 ± 1.1	23.0
	8.9^a
(24 hr)

Values represent mean ± standard error for 3-9 replicates; n=1 for KHSR.

KHSR represents a combination of four mutations: R345K, D346H, T347S, and G348R