. Author manuscript; available in PMC: 2014 Jun 1.

Published in final edited form as: Trends Endocrinol Metab. 2013 Mar 14;24(6):290–300. doi: 10.1016/j.tem.2013.02.001

TABLE 1.

P1 or Adenosine receptors:

Receptor	Agonist	Antagonist	Transduction mechanism	REF
A₁	Adenosine N6-Cyclopentyladenosine (CPA)CCPA 2′-MeCCPA GR79236 S-ENVA CVT510	Caffeine Theophylline 8-Cyclopentyl-1,3 dimethylxanthine (CPX) 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) 8-Phenyl-1,3-dipropylxanthine PSB36 N-0840 MRS1754 WRC-0571	G_i/odiminish cAMP	[3-8]
A_2A	Adenosine ATL146e CGS21680 Regadenoson HE-NECA CVT3146	Caffeine Theophylline Istradefylline SCH58261 SCH442416 ZM241385 KF17837 KW6002	G_S increase cAMP	[3-8]
A_2B	Adenosine 5′-N-ethylcarboxamidoadenosine BAY606583 LUF5835 LUF5845 NECA (non selective)	Caffeine Theophylline CVT6883 MRS1706 MRS17541 PSB603 PSB0788 PSB1115 Enprofylline MRE2029	G_S increase cAMP	[3-8]
A₃	Adenosine 2-(1-Hexynyl)-N-methyladenosine CF101 (IB-MECA) 2-Cl-IB-MECA CP532903 MRS3558 DBXRM VT160	Caffeine Theophylline MRS1191 MRS1220 MRS1334 MRS1523 MRS3777 MRE3008F20 PSB10 PSB11 VUF5574 L268605	G_i/o G_q/11 decrease cAMP and increase IP₃	[3-8]