Table 3.

Adjusted tertiles of insulin and HOMA-IR for BO cases compared with GORD controls, screening colonoscopy controls and matched colonoscopy control subset: analyses adjusted for age, gender, race (Caucasian vs other) and waist-to-hip ratio

Tertiles
	1	2	3	p Value*	1	2	3	p Value*	1	2	3	p Value*
	BO cases vs GORD controls				BO cases vs screening colonoscopy controls				BO cases vs matched colonoscopy controls
Insulin
Range, μIU/ml	<3.96	3.96–9.79	>9.79	0.21	<3.8	3.8–7.27	>7.27	0.007	<4.30	4.30–7.66	>7.66	0.08
Cases	48	40	45		47	23	63		22	14	41
Controls	50	42	43		335	298	299		58	59	58
OR (95% CI)	1.0 (referent)	1.26 (0.61 to 2.60)	1.55 (0.76 to 3.15)		1.0 (referent)	0.68 (0.34 to 1.35)	2.02 (1.15 to 3.54)		1.0 (referent)	0.56 (0.25 to 1.26)	1.68 (0.86 to 3.23)
HOMA-IR
Range	<0.90	0.90–2.22	>2.22	0.25	<0.74	0.74–1.58	>1.584	0.002	<0.91	0.91–1.64	>1.64	0.06
Cases	49	37	47		45	22	66		21	14	42
Controls	50	42	43		335	299	298		58	59	58
OR (95% CI)	1.0 (referent)	1.18 (0.56 to 2.46)	1.50 (0.75 to 3.03)		1.0 (referent)	0.64 (0.32 to 1.29)	2.23 (1.26 to 3.95)		1.0 (referent)	0.54 (0.23 to 1.24)	1.74 (0.90 to 3.38)

^*p Value denotes trend across tertiles.

BO, Barrett’s oesophagus; GORD, gastro-oesophageal reflux disease; HOMA-IR, homeostatic model for assessment of insulin resistance.