Table 2.
Lifestyle and demographic factors and the risk of serrated polyps
| Variables | Serrated Polyps | P difference | Advanced Serrated Polyps | P difference | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Left | Right | Left | Right | ||||||||
|
|
|
||||||||||
| N Total | n cases | RR (95% CI) | n cases | RR (95% CI) | n cases | RR (95% CI) | n cases | (95% CI) | |||
| Family history of polyps | |||||||||||
| No | 1997 | 461 | 1.0 | 172 | 1.0 | 56 | 1.00 | 36 | 1.00 | ||
| Yes | 521 | 133 | 1.15 (0.96–1.40) | 60 | 1.39 (1.04–1.86) | 0.21 | 21 | 0.98 (0.60–1.60) | 17 | 1.42 (0.82–2.43) | 0.07 |
| Family history of CRC | |||||||||||
| No | 1831 | 435 | 1.0 | 161 | 1.0 | 48 | 1.0 | 33 | 1.0 | ||
| Yes | 687 | 159 | 1.03 (0.88–1.22) | 71 | 1.21 (0.92–1.60) | 0.19 | 29 | 1.24 (0.80–1.93) | 20 | 1.23 (0.74–2.06) | 0.22 |
| Sex | |||||||||||
| Male | 2009 | 488 | 1.0 | 181 | 1.0 | 53 | 1.0 | 44 | 1.0 | ||
| Female | 821 | 184 | 0.98 (0.84–1.14) | 80 | 1.07 (0.82–1.39) | 0.27 | 34 | 1.35 (0.87–2.08) | 24 | 1.16 (0.72–1.87) | 0.65 |
| Race | |||||||||||
| White | 2412 | 619 | 1.0 | 235 | 1.0 | 79 | 1.0 | 64 | 1.0 | ||
| Black | 193 | 31 | 0.59 (0.42–0.81) | 15 | 0.75 (0.44–1.27) | 4 | 0.54 (0.20–1.50) | 2 | 0.41 (0.11–1.55) | ||
| Hispanic | 105 | 7 | 0.31 (0.16–0.62) | 4 | 0.41 (0.15–1.09) | 3 | 0.57 (0.17–1.92) | 1 | 0.31 (0.05–2.05) | ||
| Other | 116 | 15 | 0.62 (0.38–1.00) | 7 | 0.64 (0.30–1.35) | 0.62 | 1 | 0.39 (0.05–2.82) | 1 | 0.38 (0.06–2.45) | + |
| Age (yrs.) | |||||||||||
| < 61 years | 1409 | 352 | 1.0 | 140 | 1.0 | 53 | 1.0 | 37 | 1.0 | ||
| ≥ 61 years | 1421 | 320 | 0.94 (0.82–1.08) | 121 | 0.86 (0.68–1.10) | 0.71 | 34 | 0.98 (0.63–1.51) | 31 | 1.06 (0.67–1.68) | 0.59 |
| Body Mass Index (kg/m2) | |||||||||||
| <25 | 903 | 191 | 1.0 | 81 | 1.0 | 25 | 1.0 | 25 | 1.0 | ||
| 25 to 29.9 | 1355 | 308 | 1.09 (0.92–1.28) | 113 | 0.96 (0.73–1.27) | 38 | 1.11 (0.68–1.83 | 38 | 0.84 (0.49–1.45) | ||
| ≥ 30 | 648 | 172 | 1.27 (1.06–1.53) | 65 | 1.13 (0.83–1.56) | 0.59 | 21 | 1.64 (0.97–2.79) | 21 | 1.33 (0.75–2.36) | 0.52 |
| P for trend | 0.01 | 0.48 | 0.07 | 0.35 | |||||||
| Smoking* | |||||||||||
| Never | 1027 | 163 | 1.0 | 95 | 1.0 | 22 | 1.0 | 23 | 1.0 | ||
| Former | 1272 | 333 | 1.67 (1.41–1.97) | 113 | 0.98 (0.75–1.28) | 39 | 1.74 (1.02–2.98) | 32 | 1.21 (0.72–2.03) | ||
| Current | 511 | 173 | 2.18 (1.80–2.65) | 52 | 1.11 (0.80–1.54) | 0.0001 | 26 | 3.42 (1.91–6.11) | 13 | 1.51 (0.80–2.86) | 0.94 |
| Alcohol | |||||||||||
| Non-drinker | 856 | 192 | 1.0 | 85 | 1.0 | 24 | 1.0 | 19 | 1.0 | ||
| Drinker | 1849 | 457 | 1.05 (0.90–1.22) | 164 | 0.88 (0.68–1.14) | 0.12 | 62 | 1.19 (0.73–1.92) | 48 | 1.20 (0.73–1.98) | 0.94 |
*
RR adjusted for age, sex, center, treatment, time since randomization, study number, and smoking status (when not the stratifying variable)
+
Results could not be calculated because model did not converge.