Figure 7.

Expression profiles of Pdx1, GAD/GABA_ARα1 and insulin in mouse β-cell progenitors at E15.5, E18.5, P1 and P7. During development, cells in the pancreas express different levels of Pdx1. At E15.5, pancreatic cells that display a high level of Pdx1 express GAD and GABA_ARα1 (illustrated as green cells), and some of them also express insulin (shown as yellow cells). From E18.5 to P7, the high Pdx1-expressing cells tend to cluster as groups in the islet; and increasingly more of them express insulin.