Figure 1.

Cisplatin reduces cell viability and proliferation in breast cancer cells. (A) BT-549, (B) MDA-MB-231, (C) MDA-MD-468, and (D) MCF-7 breast cancer cells cultured without or with 20 μM cisplatin for 24 h. The bar charts show the effect of cisplatin at increasing concentrations (2.5, 5, 10, and 20 μM) on cell viability and proliferation in the BT-549, MDA-MB-231, MDA-MD-468, and MCF-7 respectively, which were determined by MTS (white bars) and BrdU (black bars) assays. Experiments were done in quadruplicate in three independent experiments. Bars are presented as mean ± SD (n = 3). *p ≤ 0.05; **p ≤ 0.0005; ***p ≤ 0.0001.