Figure 7.

A proposed model of cellular hierarchy in breast cancer cells and how it is influenced by cisplatin. The diagram illustrates a possible mechanism of cisplatin effects in breast cancer cells. Cancer stem cells can differentiate, potentially through progenitor steps, into a more mature epithelial phenotype, luminal, or myoepithelial, which has lost or possesses limited proliferative potential. As the more differentiated cells are more susceptible to chemotherapy, this push of differentiation may assist in the management and/or treatment of breast cancer.