Table 1. Randomized controlled trials with oxytocin administration in clinical groups.
| Author | Disorder | N | Age mean (years) (range) | Gender (% male) | Outcome | Task or setting |
|---|---|---|---|---|---|---|
| Andari et al.96 | Autism | 13 | 26 (17–39) | 85 | Social decision | Cyberball |
| Guastella et al.95 | Autism | 16 | 15 (12–19) | 100 | Emotion recognition | Reading the Mind in the Eyes Test |
| Hollander et al.93 | Autism | 15 | 33 (19–56) | 93 | Emotion recognition | Vocal intonation |
| Tauber et al.99 | Prader–Willi | 24 | 29 (18–43) | 33 | Social behavior | 2-Day observation |
| Guastella et al.1 | Anxiety | 25 | 42 (25–65) | 100 | Social anxiety | Self-report and clinician ratings |
| Hall et al.102 | Anxiety | 10 | 21 (13–28) | 100 | Eye gaze | Social interaction |
| Labuschagne et al.100 | Anxiety | 18 | 29 (19–55) | 100 | Amygdala response | Fearful faces |
| Pitman et al.103 | PTSD | 30 | 44 (NR) | 100 | (Neuro-)physiological responses | Personal combat imagery |
| Yatzkar and Klein104 | PTSD | 18 | NR (NR) | 100 | PTSD symptoms | Self-report |
| Mah et al.106 | Depression | 25 | 28 (19–38) | 0 | Mood | Self-assessment Manikin |
| Pincus et al.105 | Depression | 8 | 35 (26–60) | 0 | Emotion recognition | Reading the Mind in the Eyes Test |
| Averbeck et al.111 | Schizophrenia | 21 | 38 (NR) | 100 | Emotion recognition | Hexagon emotion discrimination task |
| Feifel et al.108 | Schizophrenia | 15 | 48 (NR) | 80 | Schizophrenic symptoms | clinical ratings positive and negative symptom Scale |
| Goldman et al.112 | Schizophrenia | 13 | 47 (NR) | 54 | Emotion recognition | Pictures varying in intensity of emotion |
| Pedersen et al.110 | Schizophrenia | 20 | 37 (18–55) | 85 | Schizophrenic symptoms | Clinical ratings Positive and Negative Symptom Scale |
| Den Boer and Westenberg113 | OCD | 12 | 39 (NR) | 25 | Obsessive/compulsive behaviors | self-report |
| Epperson et al.114 | OCD | 7 | 46 (NR) | 57 | Obsessive/compulsive behaviors | Clinical rating Y-BOCS |
| Epperson et al.115 | OCD | 2 | 31 (30–33) | 0 | Hair pulling | Self-report |
| Bartz et al.63 | BPD | 14 | 35 (NR) | 29 | Trust and cooperation | Assurance game |
Abbreviations: BPD, borderline personality disorder; OCD, obsessive-compulsive disorder; NR, not reported; PTSD, post-traumatic stress disorder; Y-BCOS, Yale–Brown Obsessive Compulsive Scale.