Skip to main content
. 2013 May 21;3(5):e259. doi: 10.1038/tp.2013.35

Figure 5.

Figure 5

Differential expression of SLC1A1 transcripts in human lymphocytes derived from control subjects and subjects with obsessive-compulsive disorder (OCD). Peripheral lymphocytes were isolated from unrelated controls and individuals with OCD, and cultured with the indicated reagents. All subjects with OCD were treated with serotonin reuptake inhibitors (none were on antipsychotics) except for one drug-naive (unmedicated) female subject with OCD as indicated. Lymphocytes were processed as described in the Materials and methods. Gene expression levels were normalized to β2-microglobulin levels, expressed on a logarithmic scale and shown for each individual. (a) Comparative expression of SLC1A1/EAAC1 (P1 transcript) in peripheral lymphocytes under untreated conditions, treated with 1 μℳ dopamine for 24 h or treated with 10 μℳ fluoxetine for 24 h in controls and OCD. (b) Basal levels of expression (no treatment) of each SLC1A1 isoform in lymphocytes from the control or OCD group. (c) Comparative expression of each SLC1A1 isoform in lymphocytes treated with 10 μℳ retinoic acid for 24 h.