Figure 2.

Connectivity analyses (with the right dorsolateral prefrontal cortex (DLPFC) as the seed region) revealing brain regions with significant interaction between group and telomerase activity, and the corresponding scatter plots that depict correlations within each group. (a) The medial OFC, EC, OP, ACC and STG showed significant interactions between group and telomerase activity. The left side of the brain is shown on the left. The template brain image is the bias-corrected average image from all participants. Coordinates are in MNI space. (b) Scatter plots showing significant negative correlations between telomerase activity and OFC/EC/OP/ACC, positive correlation between telomerase activity and STG for the heroin users (left panel), positive correlation between telomerase activity and EC, and nonsignificant (ns) correlation between telomerase activity and OFC/OP/ACC/STG for the healthy controls (right panel). Individual points are not presented for reason of clarity. GM, gray matter; WM,white matter; r=Pearson's correlation coefficient, P=associated P-value.