Table 2. Whole-brain structural analyses revealing interactions between group (heroin users and controls) and telomerase activity.
| Anatomical region | Laterality | x | y | z | Number of voxels | Peak t-value |
|---|---|---|---|---|---|---|
| Association between telomerase activity and GM | ||||||
| Controls>heroin users | ||||||
| No suprathreshold cluster | – | – | – | – | – | |
| Heroin users>controls | ||||||
| Middle frontal gyrus (DLPFC) | R | 36 | 12 | 51 | 184 | 3.93 |
| Association between telomerase activity and WM | ||||||
| Controls>heroin users | ||||||
| No suprathreshold cluster | – | – | – | – | – | |
| Heroin users>controls | ||||||
| DLPFC | R | 29 | −6 | 43 | 201 | 3.62 |
Abbreviations: DLPFC, dorsolateral prefrontal cortex; GM, grey matter; L, left; R, right; WM, white matter.
Years of education and Hospital Anxiety and Depression Scale scores were included as covariates of no interest. The statistical threshold was set at P<0.001, corrected for cluster-size extent with a minimum of 156 (GM) or 147 (WM) voxels within a cluster in order to be classified as significant (AlphaSim corrected P<0.05). Coordinates are in Montreal Neurological Institute space.