Table 3. Whole-brain connectivity analyses revealing interactions between group (heroin users and controls) and telomerase activity.
| Anatomical region | Laterality | x | y | z | Number of voxels | Peak t-value |
|---|---|---|---|---|---|---|
| Controls>heroin users | ||||||
| Medial orbitofrontal cortex | L | −12 | 36 | −21 | 34 | 4.10 |
| Entorhinal cortex | L | −18 | 9 | −27 | 27 | 3.85 |
| Superior occipitoparietal cortex | R | 30 | -81 | 48 | 38 | 3.48 |
| 21 | −84 | 48 | 3.11 | |||
| Anterior cingulate cortex | B | 3 | 27 | 18 | 42 | 3.28 |
| 0 | 27 | 30 | 2.99 | |||
| Heroin users>controls | ||||||
| Superior temporal gyrus | R | 57 | −27 | 9 | 135 | 4.47 |
| 63 | −9 | 3 | 3.12 | |||
Abbreviations: B, bilateral; L, left; R, right.
The seed region was chosen as the right dorsolateral prefrontal cortex gray matter cluster identified from the structural brain analyses. Years of education and Hospital Anxiety and Depression Scale scores were included as covariates of no interest. The statistical threshold was set at P<0.005, with a minimum of 26 voxels within a cluster in order to be classified as significant (AlphaSim corrected P<0.05). Coordinates are in Montreal Neurological Institute space.