Table 1. Family-based association tests for ANK3 variants and haplotypes under additive model.

Marker	Over-transmitted	Allele frequency	Z-score	P-value	Adjusted P-valuea
rs1380455	T	0.728	2.108	0.035	0.193
rs16914968	T	0.076	1.643	0.100	0.470
rs1551684	C	0.914	1.111	0.267	0.844
rs3808942	T	0.745	0.094	0.925	1.000
rs3808943	T	0.311	2.430	0.015	0.087
rs10994336	T	0.310	1.939	0.053	0.276
Haplotype	Informative families	Haplotype frequency	Z-score	P-value	Permutation P-valueb
TCCTTT	103	0.315	2.266	0.023	0.035*
GCCTCC	111	0.279	−1.572	0.116	0.126
TCCCCC	100	0.247	−0.565	0.572	0.552
TCTTCC	43	0.070	−0.778	0.436	0.396
TTCTCC	39	0.069	1.737	0.082	0.079

Abbreviation: ANK3, ankyrin-G.

^aBonferroni-adjusted P-values.

^bP-values derived from 10 000 permutations; *denotes statistical significance.

Non-adjusted P-values <0.05 are in bold.