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Mutation Y677A in p85β-cSH2 Releases Inhibitory Effect on p110β
(A) Kinase activity (ADP formation) of p110β in a complex with p85β-icSH2-Y677A (Y677A-ic) compared to the wild-type complex (ic) in the absence and presence of 10 μM PDGFR pY2 (ADP formation on the y axis expressed as in Figure 1B).
(B) Comparison of p110β activities of 1 nM complexes with wild-type or Y677 mutant nicSH2 or icSH2 (activity shown as in Figure 1D).
