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. 2011 Mar 4;41(5):567–578. doi: 10.1016/j.molcel.2011.01.026

Figure 6.

Figure 6

Structural Basis for p110β Regulation by p85β-iSH2 Domain

(A) Close-up of interactions between p85β-iSH2 (blue) and p110β activation loop.

(B) Stereo view of the unique interaction between the iSH2 (blue) with the ABD-RBD linker of p110β (orange), as compared to p110α (white).

(C) Detailed interactions between residues in the iSH2 (green sticks) with residues in the C2 domain of p110β (magenta sticks). The CBR3 (Cβ5/Cβ6 loop) and Cβ7/Cβ8 loops that contact the iSH2 are highlighted in yellow and pink, respectively.