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(A) Novel ring-opening, decarboxylative mechanism for inactivation of SPT by LCS. Path (a) denotes an enzymatic, nucleophile(Nu)-mediated mechanism with an acylated intermediate. Path (b) is the direct hydrolytic mechanism. (B) Inactivation of SPT by DCS highlighting a proposed quinonoid intermediate observed in the SPT R378N mutant. The paths are the same as in (A).
