Table 2.
Incidence Rates and Hazard Ratios for Ischemic Stroke*
| All | Women | Men | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HIV | Control | IRR (95% CI) |
P value |
HIV | Control | IRR (95% CI) |
P value |
HIV | Control | IRR (95% CI) |
P value |
||
| Events | 132 | 782 | 40 | 177 | 92 | 605 | |||||||
| Age Group | |||||||||||||
| 18-29 | 25 | 3.87 | 0.88 | 4.42 (1.56- 11.09) |
0.004 | 5.83 | 0.79 | 7.34 (1.93- 24.39) |
0.002 | 2.11 | 0.98 | 2.15 (0.23- 10.40) |
0.351 |
| 30-39 | 82 | 3.00 | 1.02 | 2.96 (1.69-4.96) | <0.001 | 3.29 | 0.62 | 5.31 (1.95- 13.34) |
<0.001 | 2.84 | 1.28 | 2.23 (1.07-4.26) | 0.022 |
| 40-49 | 229 | 4.02 | 2.62 | 1.53 (1.06-2.17) | 0.02 | 3.90 | 1.67 | 2.34 (1.08-4.65) | 0.021 | 4.06 | 3.09 | 1.31 (0.84-1.97) | 0.194 |
| 50-59 | 256 | 5.01 | 6.09 | 0.82 (0.52-1.24) | 0.355 | 3.76 | 3.81 | 0.99 (0.31-2.49) | 0.999 | 5.46 | 7.06 | 0.77 (0.46-1.23) | 0.272 |
| 60-69 | 174 | 17.60 | 13.19 | 1.33 (0.83-2.06) | 0.198 | 18.47 | 7.34 | 2.52 (0.85-6.25) | 0.063 | 17.33 | 15.84 | 1.09 (0.63-1.80) | 0.702 |
| 70-79 | 101 | 32.86 | 23.17 | 1.42 (0.71-2.60) | 0.264 | 17.17 | 17.45 | 0.98 (0.11-3.92) | 0.999 | 40.20 | 27.03 | 1.49 (0.68-2.92) | 0.254 |
| >=80 | 47 | 30.47 | 29.40 | 1.04 (0.32-2.62) | 0.895 | 34.19 | 22.26 | 1.54 (0.29-5.31) | 0.485 | 26.19 | 37.60 | 0.70 (0.08-2.79) | 0.681 |
| Models | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||||||||
| Unadjusted | 5.27 | 3.75 | 1.40 (1.17-1.69) | <0.001 | 5.02 | 2.31 | 2.16 (1.53-3.04) | <0.001 | 5.38 | 4.59 | 1.18 (0.95-1.47) | 0.14 | |
| Model 1† | 1.34 (1.11-1.61) | 0.002 | 2.02 (1.43-2.86) | <0.001 | 1.17 (0.94-1.46) | 0.165 | |||||||
| Model 2‡ | 1.21 (1.01-1.46) | 0.043 | 1.76 (1.24-2.52) | 0.002 | 1.05 (0.84-1.32) | 0.639 | |||||||
Abbreviations: IRR = incidence rate ratio; CI = confidence interval; HR = hazard ratio.
*
Rates are per 1000 person years.
†
Adjusted for age, gender, and race (white vs. other race).
‡
Adjusted for variables in model 1 and hypertension, diabetes, dyslipidemia, smoking (ever vs. never), structural heart disease (at least one diagnosis of cardiomyopathy, left-sided valvular heart disease, or heart failure), atrial fibrillation/flutter, aspirin use, warfarin use.